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1662: Medium Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
April 15, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 57 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 13,420
  2. Avatar for Go Science 2. Go Science 71 pts. 13,403
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 49 pts. 13,362
  4. Avatar for Beta Folders 4. Beta Folders 33 pts. 13,360
  5. Avatar for Void Crushers 5. Void Crushers 22 pts. 13,238
  6. Avatar for Contenders 6. Contenders 14 pts. 13,238
  7. Avatar for Marvin's bunch 7. Marvin's bunch 8 pts. 13,142
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 5 pts. 13,032
  9. Avatar for Russian team 9. Russian team 3 pts. 12,957
  10. Avatar for GENE 433 10. GENE 433 2 pts. 12,725
  1. Avatar for diamonddays 81. diamonddays Lv 1 1 pt. 11,985
  2. Avatar for Flagg65a 82. Flagg65a Lv 1 1 pt. 11,972
  3. Avatar for Merf 83. Merf Lv 1 1 pt. 11,863
  4. Avatar for Altercomp 84. Altercomp Lv 1 1 pt. 11,816
  5. Avatar for alwen 85. alwen Lv 1 1 pt. 11,770
  6. Avatar for lconor 86. lconor Lv 1 1 pt. 11,764
  7. Avatar for oureion 87. oureion Lv 1 1 pt. 11,666
  8. Avatar for carsonfb 88. carsonfb Lv 1 1 pt. 11,633
  9. Avatar for pandapharmd 89. pandapharmd Lv 1 1 pt. 11,581
  10. Avatar for jdmclure 90. jdmclure Lv 1 1 pt. 11,401

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1000 +825)
Penalizes extra residues inserted beyond the starting 75, at a cost of 55 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

bkoep Staff Lv 1

That was an error in the Objective description, and has been corrected.