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1669: Extra Small Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
April 30, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 55 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 2 pts. 11,439
  2. Avatar for DW 2020 12. DW 2020 1 pt. 11,366
  3. Avatar for HMT heritage 13. HMT heritage 1 pt. 11,278
  4. Avatar for Team South Africa 14. Team South Africa 1 pt. 11,210
  5. Avatar for freefolder 15. freefolder 1 pt. 11,066
  6. Avatar for MBB190 16. MBB190 1 pt. 10,239
  7. Avatar for I3L GANG 17. I3L GANG 1 pt. 10,184
  8. Avatar for Deleted group 18. Deleted group pts. 0
  1. Avatar for actiasluna
    1. actiasluna Lv 1
    100 pts. 12,222
  2. Avatar for johnmitch 2. johnmitch Lv 1 97 pts. 12,149
  3. Avatar for silent gene 3. silent gene Lv 1 94 pts. 12,139
  4. Avatar for retiredmichael 4. retiredmichael Lv 1 90 pts. 12,128
  5. Avatar for Skippysk8s 5. Skippysk8s Lv 1 87 pts. 12,105
  6. Avatar for LociOiling 6. LociOiling Lv 1 84 pts. 12,091
  7. Avatar for anthion 7. anthion Lv 1 81 pts. 12,088
  8. Avatar for reefyrob 8. reefyrob Lv 1 78 pts. 12,030
  9. Avatar for dcrwheeler 9. dcrwheeler Lv 1 75 pts. 12,017
  10. Avatar for NinjaGreg 10. NinjaGreg Lv 1 73 pts. 12,005

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 60, at a cost of 55 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.