Placeholder image of a protein
Icon representing a puzzle

1672: Large Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
May 08, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DW 2020 11. DW 2020 1 pt. 12,973
  2. Avatar for I3L GANG 12. I3L GANG 1 pt. 12,750
  3. Avatar for HMT heritage 13. HMT heritage 1 pt. 12,688
  4. Avatar for freefolder 14. freefolder 1 pt. 10,538
  5. Avatar for GENE 433 15. GENE 433 1 pt. 0
  6. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 0
  7. Avatar for FoldIt@Netherlands 17. FoldIt@Netherlands 1 pt. 0
  1. Avatar for toshiue
    1. toshiue Lv 1
    100 pts. 14,190
  2. Avatar for Hollinas 2. Hollinas Lv 1 82 pts. 14,173
  3. Avatar for Dantoto 3. Dantoto Lv 1 66 pts. 14,168
  4. Avatar for Phyx 4. Phyx Lv 1 53 pts. 14,168
  5. Avatar for actiasluna 5. actiasluna Lv 1 42 pts. 14,136
  6. Avatar for Skippysk8s 6. Skippysk8s Lv 1 33 pts. 14,131
  7. Avatar for Bruno Kestemont 7. Bruno Kestemont Lv 1 26 pts. 14,060
  8. Avatar for LociOiling 8. LociOiling Lv 1 20 pts. 14,045
  9. Avatar for Blipperman 9. Blipperman Lv 1 15 pts. 14,042
  10. Avatar for smilingone 10. smilingone Lv 1 11 pts. 14,035

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1100)
Penalizes extra residues inserted beyond the starting 85, at a cost of 55 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.