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1672: Large Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
May 08, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DW 2020 11. DW 2020 1 pt. 12,973
  2. Avatar for I3L GANG 12. I3L GANG 1 pt. 12,750
  3. Avatar for HMT heritage 13. HMT heritage 1 pt. 12,688
  4. Avatar for freefolder 14. freefolder 1 pt. 10,538
  5. Avatar for GENE 433 15. GENE 433 1 pt. 0
  6. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 0
  7. Avatar for FoldIt@Netherlands 17. FoldIt@Netherlands 1 pt. 0
  1. Avatar for leannerikicheever 101. leannerikicheever Lv 1 1 pt. 11,439
  2. Avatar for dd-2 102. dd-2 Lv 1 1 pt. 11,425
  3. Avatar for nadinelim 103. nadinelim Lv 1 1 pt. 11,394
  4. Avatar for komnor 104. komnor Lv 1 1 pt. 11,374
  5. Avatar for janikavillamor 105. janikavillamor Lv 1 1 pt. 11,370
  6. Avatar for SiPot2018 106. SiPot2018 Lv 1 1 pt. 11,314
  7. Avatar for chloebborromeo 107. chloebborromeo Lv 1 1 pt. 11,229
  8. Avatar for aresescul 108. aresescul Lv 1 1 pt. 10,919
  9. Avatar for harvardman 109. harvardman Lv 1 1 pt. 10,905
  10. Avatar for agcantos 110. agcantos Lv 1 1 pt. 10,768

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1100)
Penalizes extra residues inserted beyond the starting 85, at a cost of 55 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.