Placeholder image of a protein
Icon representing a puzzle

1672: Large Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
May 08, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 14,190
  2. Avatar for Gargleblasters 2. Gargleblasters 73 pts. 14,175
  3. Avatar for Beta Folders 3. Beta Folders 52 pts. 14,045
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 36 pts. 14,033
  5. Avatar for Void Crushers 5. Void Crushers 24 pts. 13,963
  6. Avatar for Marvin's bunch 6. Marvin's bunch 16 pts. 13,940
  7. Avatar for Russian team 7. Russian team 10 pts. 13,863
  8. Avatar for Contenders 8. Contenders 6 pts. 13,791
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 4 pts. 13,715
  10. Avatar for Hold My Beer 10. Hold My Beer 2 pts. 13,445
  1. Avatar for Lyshi2018 51. Lyshi2018 Lv 1 10 pts. 12,973
  2. Avatar for kludbrook 52. kludbrook Lv 1 10 pts. 12,953
  3. Avatar for cbwest 53. cbwest Lv 1 9 pts. 12,927
  4. Avatar for throwing 54. throwing Lv 1 9 pts. 12,926
  5. Avatar for Dantoto 55. Dantoto Lv 1 8 pts. 12,914
  6. Avatar for thewholeblahthing 56. thewholeblahthing Lv 1 8 pts. 12,895
  7. Avatar for rezaefar 57. rezaefar Lv 1 7 pts. 12,894
  8. Avatar for abiogenesis 58. abiogenesis Lv 1 7 pts. 12,890
  9. Avatar for momadoc 59. momadoc Lv 1 7 pts. 12,876
  10. Avatar for fearjuan 60. fearjuan Lv 1 6 pts. 12,866

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1100)
Penalizes extra residues inserted beyond the starting 85, at a cost of 55 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.