Placeholder image of a protein
Icon representing a puzzle

1678: Extra Large Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
May 22, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DW 2020 11. DW 2020 1 pt. 13,509
  2. Avatar for Extraterrestrials 2.0 12. Extraterrestrials 2.0 1 pt. 13,258
  3. Avatar for freefolder 13. freefolder 1 pt. 12,191
  4. Avatar for Alpha Rays 14. Alpha Rays 1 pt. 11,770
  1. Avatar for pvc78 31. pvc78 Lv 1 22 pts. 14,053
  2. Avatar for Bautho 32. Bautho Lv 1 21 pts. 14,048
  3. Avatar for MicElephant 33. MicElephant Lv 1 19 pts. 14,019
  4. Avatar for smilingone 34. smilingone Lv 1 18 pts. 14,008
  5. Avatar for christioanchauvin 35. christioanchauvin Lv 1 17 pts. 14,002
  6. Avatar for phi16 36. phi16 Lv 1 16 pts. 13,937
  7. Avatar for alcor29 37. alcor29 Lv 1 15 pts. 13,899
  8. Avatar for alwen 38. alwen Lv 1 14 pts. 13,868
  9. Avatar for guineapig 39. guineapig Lv 1 13 pts. 13,816
  10. Avatar for benrh 40. benrh Lv 1 13 pts. 13,765

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1375)
Penalizes extra residues inserted beyond the starting 95, at a cost of 55 points per residue. Players may use up to 120 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.