Placeholder image of a protein
Icon representing a puzzle

1678: Extra Large Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
May 22, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DW 2020 11. DW 2020 1 pt. 13,509
  2. Avatar for Extraterrestrials 2.0 12. Extraterrestrials 2.0 1 pt. 13,258
  3. Avatar for freefolder 13. freefolder 1 pt. 12,191
  4. Avatar for Alpha Rays 14. Alpha Rays 1 pt. 11,770
  1. Avatar for diamonddays 61. diamonddays Lv 1 3 pts. 13,169
  2. Avatar for yasmin_waydzik 62. yasmin_waydzik Lv 1 3 pts. 13,151
  3. Avatar for Dhalion 63. Dhalion Lv 1 2 pts. 13,095
  4. Avatar for Willyanto 64. Willyanto Lv 1 2 pts. 13,069
  5. Avatar for nong9090 65. nong9090 Lv 1 2 pts. 13,064
  6. Avatar for jobo0502 66. jobo0502 Lv 1 2 pts. 13,042
  7. Avatar for rabamino12358 67. rabamino12358 Lv 1 2 pts. 13,030
  8. Avatar for thewholeblahthing 68. thewholeblahthing Lv 1 2 pts. 13,024
  9. Avatar for YeshuaLives 69. YeshuaLives Lv 1 2 pts. 13,011
  10. Avatar for lconor 70. lconor Lv 1 1 pt. 12,962

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1375)
Penalizes extra residues inserted beyond the starting 95, at a cost of 55 points per residue. Players may use up to 120 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.