Placeholder image of a protein
Icon representing a puzzle

1678: Extra Large Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
May 22, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 14,865
  2. Avatar for Go Science 2. Go Science 68 pts. 14,788
  3. Avatar for Beta Folders 3. Beta Folders 44 pts. 14,748
  4. Avatar for Contenders 4. Contenders 27 pts. 14,746
  5. Avatar for Void Crushers 5. Void Crushers 16 pts. 14,646
  6. Avatar for Anthropic Dreams 6. Anthropic Dreams 9 pts. 14,640
  7. Avatar for Marvin's bunch 7. Marvin's bunch 5 pts. 14,463
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 3 pts. 14,353
  9. Avatar for Russian team 9. Russian team 1 pt. 14,112
  10. Avatar for Hold My Beer 10. Hold My Beer 1 pt. 13,553
  1. Avatar for Timo van der Laan 21. Timo van der Laan Lv 1 38 pts. 14,402
  2. Avatar for nicobul 22. nicobul Lv 1 36 pts. 14,353
  3. Avatar for Bletchley Park 23. Bletchley Park Lv 1 34 pts. 14,332
  4. Avatar for NinjaGreg 24. NinjaGreg Lv 1 33 pts. 14,321
  5. Avatar for jamiexq 25. jamiexq Lv 1 31 pts. 14,288
  6. Avatar for Anfinsen_slept_here 26. Anfinsen_slept_here Lv 1 29 pts. 14,277
  7. Avatar for Deleted player 27. Deleted player pts. 14,268
  8. Avatar for stomjoh 28. stomjoh Lv 1 26 pts. 14,193
  9. Avatar for Blipperman 29. Blipperman Lv 1 25 pts. 14,174
  10. Avatar for aznarog 30. aznarog Lv 1 23 pts. 14,153

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1375)
Penalizes extra residues inserted beyond the starting 95, at a cost of 55 points per residue. Players may use up to 120 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.