Placeholder image of a protein
Icon representing a puzzle

1684: Symmetric Dimer Design: 60 Residues

Closed since almost 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 07, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. We've omitted the "Core Exists: Complex" objective to simplify the puzzle, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 17,472
  2. Avatar for Go Science 2. Go Science 68 pts. 17,460
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 44 pts. 17,184
  4. Avatar for Marvin's bunch 4. Marvin's bunch 27 pts. 17,164
  5. Avatar for Beta Folders 5. Beta Folders 16 pts. 17,161
  6. Avatar for Void Crushers 6. Void Crushers 9 pts. 16,791
  7. Avatar for Contenders 7. Contenders 5 pts. 16,739
  8. Avatar for Russian team 8. Russian team 3 pts. 16,304
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 1 pt. 16,255
  10. Avatar for HMT heritage 10. HMT heritage 1 pt. 16,010
  1. Avatar for cobaltteal 91. cobaltteal Lv 1 1 pt. 10,670
  2. Avatar for rol 92. rol Lv 1 1 pt. 10,569
  3. Avatar for Divisor11 93. Divisor11 Lv 1 1 pt. 10,442
  4. Avatar for frostschutz 94. frostschutz Lv 1 1 pt. 10,225
  5. Avatar for dbuske 95. dbuske Lv 1 1 pt. 9,998
  6. Avatar for ScyllaHide 96. ScyllaHide Lv 1 1 pt. 9,939
  7. Avatar for kentish_alex 97. kentish_alex Lv 1 1 pt. 9,814
  8. Avatar for zsumierp 98. zsumierp Lv 1 1 pt. 9,771
  9. Avatar for TastyMunchies 99. TastyMunchies Lv 1 1 pt. 9,747
  10. Avatar for Biochemica 100. Biochemica Lv 1 1 pt. 9,113

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +1700)
Ensures that at least 17 residues are buried in the core of the monomer unit.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

LociOiling Lv 1

The conditions don't mind if the two chains are far apart. Of course, your score may improve if they are….