Placeholder image of a protein
Icon representing a puzzle

1686: Symmetric Trimer Design: 70 Residues

Closed since almost 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 14, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. There is no "Core Exists: Complex" objective, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Hold My Beer 11. Hold My Beer 1 pt. 16,105
  2. Avatar for I3L GANG 12. I3L GANG 1 pt. 13,264
  3. Avatar for BOINC@Poland 13. BOINC@Poland 1 pt. 11,558
  4. Avatar for Trinity Biology 14. Trinity Biology 1 pt. 6,402
  5. Avatar for 1502-2019 1 15. 1502-2019 1 1 pt. 0
  6. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 0
  1. Avatar for Dantoto 61. Dantoto Lv 1 2 pts. 14,407
  2. Avatar for harvardman 62. harvardman Lv 1 1 pt. 14,272
  3. Avatar for abiogenesis 63. abiogenesis Lv 1 1 pt. 14,246
  4. Avatar for Arne Heessels 64. Arne Heessels Lv 1 1 pt. 14,171
  5. Avatar for cbwest 65. cbwest Lv 1 1 pt. 14,143
  6. Avatar for zico_riteh 66. zico_riteh Lv 1 1 pt. 14,124
  7. Avatar for ManVsYard 67. ManVsYard Lv 1 1 pt. 13,998
  8. Avatar for JSmith48 68. JSmith48 Lv 1 1 pt. 13,765
  9. Avatar for pfirth 69. pfirth Lv 1 1 pt. 13,552
  10. Avatar for Silvercraft 70. Silvercraft Lv 1 1 pt. 13,528

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2000)
Ensures that at least 17 residues are buried in the core of the monomer unit.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.