Placeholder image of a protein
Icon representing a puzzle

1692: Symmetric Trimer Design: 90 Residues

Closed since over 6 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 28, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. There is no "Core Exists: Complex" objective, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Hold My Beer 11. Hold My Beer 1 pt. 16,737
  2. Avatar for BOINC@Poland 12. BOINC@Poland 1 pt. 14,955
  3. Avatar for Trinity Biology 13. Trinity Biology 1 pt. 11,222
  4. Avatar for DSN @ Home 14. DSN @ Home 1 pt. 0
  1. Avatar for actiasluna
    1. actiasluna Lv 1
    100 pts. 22,399
  2. Avatar for silent gene 2. silent gene Lv 1 96 pts. 22,331
  3. Avatar for anthion 3. anthion Lv 1 92 pts. 21,954
  4. Avatar for dcrwheeler 4. dcrwheeler Lv 1 88 pts. 21,771
  5. Avatar for grogar7 5. grogar7 Lv 1 84 pts. 21,689
  6. Avatar for johnmitch 6. johnmitch Lv 1 80 pts. 21,679
  7. Avatar for robgee 7. robgee Lv 1 76 pts. 21,661
  8. Avatar for vakobo 8. vakobo Lv 1 72 pts. 21,638
  9. Avatar for LociOiling 9. LociOiling Lv 1 69 pts. 21,629
  10. Avatar for Galaxie 10. Galaxie Lv 1 66 pts. 21,593

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +3000)
Ensures that at least 30 residues are buried in the core of the monomer unit.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.