Placeholder image of a protein
Icon representing a puzzle

1703: Symmetric Trimer Design: 70 Residues

Closed since over 6 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 24, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for BOINC@Poland 11. BOINC@Poland 1 pt. 15,128
  2. Avatar for Team South Africa 12. Team South Africa 1 pt. 14,918
  3. Avatar for Penny-Arcade 13. Penny-Arcade 1 pt. 11,333
  4. Avatar for Trinity Biology 14. Trinity Biology 1 pt. 11,125
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 1 pt. 0
  6. Avatar for Gioca con la scienza 16. Gioca con la scienza 1 pt. 0
  1. Avatar for jobo0502 21. jobo0502 Lv 1 34 pts. 17,639
  2. Avatar for Phyx 22. Phyx Lv 1 32 pts. 17,579
  3. Avatar for fiendish_ghoul 23. fiendish_ghoul Lv 1 30 pts. 17,564
  4. Avatar for jausmh 24. jausmh Lv 1 28 pts. 17,483
  5. Avatar for Blipperman 25. Blipperman Lv 1 26 pts. 17,470
  6. Avatar for georg137 26. georg137 Lv 1 25 pts. 17,372
  7. Avatar for O Seki To 27. O Seki To Lv 1 23 pts. 17,342
  8. Avatar for Mike Cassidy 28. Mike Cassidy Lv 1 22 pts. 17,269
  9. Avatar for Deleted player 29. Deleted player pts. 17,246
  10. Avatar for christioanchauvin 30. christioanchauvin Lv 1 19 pts. 17,223

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 66 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.