Placeholder image of a protein
Icon representing a puzzle

1707: Symmetric Trimer Design: 90 Residues

Closed since over 6 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 31, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 22,237
  2. Avatar for Gargleblasters 2. Gargleblasters 65 pts. 22,185
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 41 pts. 22,116
  4. Avatar for Contenders 4. Contenders 24 pts. 21,901
  5. Avatar for Go Science 5. Go Science 14 pts. 21,835
  6. Avatar for Void Crushers 6. Void Crushers 7 pts. 21,827
  7. Avatar for Marvin's bunch 7. Marvin's bunch 4 pts. 21,389
  8. Avatar for Russian team 8. Russian team 2 pts. 20,196
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 1 pt. 19,918
  10. Avatar for HMT heritage 10. HMT heritage 1 pt. 19,492
  1. Avatar for jausmh 31. jausmh Lv 1 14 pts. 19,792
  2. Avatar for O Seki To 32. O Seki To Lv 1 13 pts. 19,492
  3. Avatar for drumpeter18yrs9yrs 33. drumpeter18yrs9yrs Lv 1 12 pts. 19,482
  4. Avatar for jobo0502 34. jobo0502 Lv 1 11 pts. 19,409
  5. Avatar for WBarme1234 35. WBarme1234 Lv 1 10 pts. 19,309
  6. Avatar for alcor29 36. alcor29 Lv 1 9 pts. 19,181
  7. Avatar for godel9 37. godel9 Lv 1 9 pts. 18,719
  8. Avatar for PeterDav 38. PeterDav Lv 1 8 pts. 18,653
  9. Avatar for georg137 39. georg137 Lv 1 7 pts. 18,638
  10. Avatar for Museka 40. Museka Lv 1 7 pts. 18,109

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +3000)
Ensures that at least 30 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 102 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.