Placeholder image of a protein
Icon representing a puzzle

1718: Symmetric Dimer Design: 70 Residues

Closed since over 6 years ago

Intermediate Intermediate Overall Overall Design Design Symmetry Symmetry

Summary

Created
August 21, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. We've omitted the "Core Exists: Complex" objective to simplify the puzzle, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Team South Africa 11. Team South Africa 1 pt. 15,074
  2. Avatar for BOINC@Poland 12. BOINC@Poland 1 pt. 12,598
  3. Avatar for Window Group 13. Window Group 1 pt. 0
  1. Avatar for jdmclure 71. jdmclure Lv 1 1 pt. 11,186
  2. Avatar for rinze 72. rinze Lv 1 1 pt. 11,085
  3. Avatar for VojtenziCZE 73. VojtenziCZE Lv 1 1 pt. 10,936
  4. Avatar for frostschutz 74. frostschutz Lv 1 1 pt. 10,659
  5. Avatar for Belle36 75. Belle36 Lv 1 1 pt. 8,296
  6. Avatar for dbuske 76. dbuske Lv 1 1 pt. 7,520
  7. Avatar for Deleted player 77. Deleted player 1 pt. 3,985
  8. Avatar for Alice_C 78. Alice_C Lv 1 1 pt. 2,289
  9. Avatar for GuyWithMustache 79. GuyWithMustache Lv 1 1 pt. 0
  10. Avatar for asd456 80. asd456 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2100)
Ensures that at least 21 residues are buried in the core of the monomer unit.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.