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1723b: IL-7R Binder Redesign: Round 10

Closed since over 6 years ago

Summary

Created: September 02, 2019
Expires: September 05, 2019 at 23:00 UTC
Max points: 100

Description

Note: This puzzle replaces the original Puzzle 1723, which was incorrectly set up to allow free movement of the binding helices. Unfortunately, players will not be allowed to load solutions from the original Puzzle 1723.

Design a protein that binds IL-7R!

Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues between the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.

This is the tenth puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! The binding helices in this puzzle are the same as in Round 9, but with with the designable region between the helices instead of at their termini. Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!