1728: IL-7R Binder Redesign: Round 12

Closed since over 6 years ago

Summary

• Created: September 09, 2019
• Expires: September 13, 2019 at 23:00 UTC
• Max points: 100

Description

Design a protein that binds IL-7R!



Interleukin 7 receptor (IL-7R) is a protein that helps regulate the human immune system, and is an important target in cancer therapy research. In this puzzle, players start with two frozen helices bound to the IL-7R target (also frozen). Players can fold and design about 20 residues between the binding helices, with the goal of creating a well-folded protein that can bind the IL-7R target! Players may also redesign residues on the backside of the binding helices, but residues at the IL-7R interface are frozen in place. The most promising designs will have lots of helical and sheet structure with only short loops, and will have a well-packed, buried core. There are several Objectives in place; see the puzzle comments for details.



This is the 12th puzzle in the IL-7R binder series, meant to generate a large diversity of designs that can be tested in a high-throughput binding experiment! The binding helices in this puzzle are the same as in Round 11, but with with the designable region between the helices instead of at their termini. Due to time constraints, puzzles in this series will be online for only 4 days at a time. See the blog for more information. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. BOINC@Poland 1 pt. 10,968
• 12. Italiani Al Lavoro 1 pt. 10,797
• 13. Richard Dawkins Foundation 1 pt. 9,616
• 14. Trinity Biology 1 pt. 9,169
• 15. Mr. Gauthier's AP Classroom 1 1 pt. 6,697
• 16. Firebirds BioChem 1 pt. 0

Top soloists

• 1. LociOiling 100 pts. 11,889
• 2. Skippysk8s 95 pts. 11,706
• 3. silent gene 90 pts. 11,698
• 4. dcrwheeler 85 pts. 11,647
• 5. crpainter 80 pts. 11,609
• 6. Bletchley Park 75 pts. 11,603
• 7. Bruno Kestemont 71 pts. 11,569
• 8. anthion 67 pts. 11,566
• 9. johnmitch 63 pts. 11,534
• 10. Deleted player pts. 11,532

Comments

[spvincent]

This puzzle isn't showing up in the game.

[LociOiling]

The official details about the objectives for this puzzle are missing. Unofficially, here are the objectives from the previous round, which seem to be the same:

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +1000)
Ensures that at least 25% of residues are buried in the protein core.

SS Design (max +200)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +100)
Penalizes extra residues inserted beyond 110, at a cost of 20 points per residue. Players may use up to 115 residues in total.