Placeholder image of a protein
Icon representing a puzzle

1763: Poly-Proline Helix Design: Round 1

Closed since over 6 years ago

Intermediate Overall Design

Summary

Created
November 21, 2019
Expires
Max points
100
Description

This puzzle introduces a new secondary structure, the poly-proline helix! The starting structure is a small 38 residue protein with a frozen helix and designable residues on either end. Players should fold the starting structure to create a compact globular protein that incorporates this new type of secondary structure. Note that the backbone of the poly-proline helix has bondable oxygen atoms. If any of these oxygens are buried in the protein core, they will need to make hydrogen bonds! See the blog for more information!

Top groups

  1. Avatar for Hold My Beer 11. Hold My Beer 2 pts. 8,555
  2. Avatar for Void Crushers 12. Void Crushers 1 pt. 8,538
  3. Avatar for Rechenkraft.net 13. Rechenkraft.net 1 pt. 8,468
  4. Avatar for Team New Zealand 14. Team New Zealand 1 pt. 8,435
  5. Avatar for Team Schleswig-Holstein 15. Team Schleswig-Holstein 1 pt. 8,333
  6. Avatar for Italiani Al Lavoro 16. Italiani Al Lavoro 1 pt. 8,118
  7. Avatar for Trinity Biology 17. Trinity Biology 1 pt. 8,080
  8. Avatar for Deleted group 18. Deleted group pts. 7,865
  9. Avatar for GUGITBIOTECH 19. GUGITBIOTECH 1 pt. 7,826
  1. Avatar for NewZealand 61. NewZealand Lv 1 5 pts. 8,435
  2. Avatar for momadoc 62. momadoc Lv 1 5 pts. 8,400
  3. Avatar for manu8170 63. manu8170 Lv 1 4 pts. 8,398
  4. Avatar for cobaltteal 64. cobaltteal Lv 1 4 pts. 8,397
  5. Avatar for georg137 65. georg137 Lv 1 4 pts. 8,394
  6. Avatar for Silvercraft 66. Silvercraft Lv 1 4 pts. 8,392
  7. Avatar for heather-1 67. heather-1 Lv 1 3 pts. 8,388
  8. Avatar for tamanrasset 68. tamanrasset Lv 1 3 pts. 8,387
  9. Avatar for Bautho 69. Bautho Lv 1 3 pts. 8,370
  10. Avatar for Wipf 70. Wipf Lv 1 3 pts. 8,357

Comments

Anfinsen_slept_here Lv 1

If we are designing collagen-like structures, don't we need hydroxyproline as an amino acid?

see wikipedia

and
Gorres, Kelly L.; Raines, Ronald T. (April 2010). "Prolyl 4-hydroxylase". Critical Reviews in Biochemistry and Molecular Biology. 45 (2): 106–124.

Deleted user

Collagen happens to contain hydroxyproline (a non-canonical amino acid), but poly-proline helices (and proteins that incorporate them) do not need to contain this residue. Currently Foldit works best with the 20 encoded amino acids, so we try to design puzzles with only these residues.

bkoep Staff Lv 1

Sorry, that was an oversight! We will be sure to include the Blueprint in future puzzles!