Placeholder image of a protein
Icon representing a puzzle

1763: Poly-Proline Helix Design: Round 1

Closed since over 6 years ago

Intermediate Overall Design

Summary

Created
November 21, 2019
Expires
Max points
100
Description

This puzzle introduces a new secondary structure, the poly-proline helix! The starting structure is a small 38 residue protein with a frozen helix and designable residues on either end. Players should fold the starting structure to create a compact globular protein that incorporates this new type of secondary structure. Note that the backbone of the poly-proline helix has bondable oxygen atoms. If any of these oxygens are buried in the protein core, they will need to make hydrogen bonds! See the blog for more information!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 8,800
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 76 pts. 8,747
  3. Avatar for Beta Folders 3. Beta Folders 56 pts. 8,736
  4. Avatar for Gargleblasters 4. Gargleblasters 41 pts. 8,729
  5. Avatar for Russian team 5. Russian team 29 pts. 8,682
  6. Avatar for Contenders 6. Contenders 20 pts. 8,678
  7. Avatar for Marvin's bunch 7. Marvin's bunch 14 pts. 8,664
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 9 pts. 8,655
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 6 pts. 8,635
  10. Avatar for HMT heritage 10. HMT heritage 4 pts. 8,581
  1. Avatar for andromeda72 121. andromeda72 Lv 1 1 pt. 6,384
  2. Avatar for hada 122. hada Lv 1 1 pt. 6,239
  3. Avatar for RileyBugz1 123. RileyBugz1 Lv 1 1 pt. 6,193
  4. Avatar for heyubob 124. heyubob Lv 1 1 pt. 6,188
  5. Avatar for SeoYeon 125. SeoYeon Lv 1 1 pt. 6,167
  6. Avatar for KpX 126. KpX Lv 1 1 pt. 6,165
  7. Avatar for Susume 127. Susume Lv 1 1 pt. 5,204
  8. Avatar for Hollinas 128. Hollinas Lv 1 1 pt. 5,204
  9. Avatar for alwen 129. alwen Lv 1 1 pt. 5,204
  10. Avatar for bkoep 130. bkoep Lv 1 1 pt. 5,204

Comments

Anfinsen_slept_here Lv 1

If we are designing collagen-like structures, don't we need hydroxyproline as an amino acid?

see wikipedia

and
Gorres, Kelly L.; Raines, Ronald T. (April 2010). "Prolyl 4-hydroxylase". Critical Reviews in Biochemistry and Molecular Biology. 45 (2): 106–124.

Deleted user

Collagen happens to contain hydroxyproline (a non-canonical amino acid), but poly-proline helices (and proteins that incorporate them) do not need to contain this residue. Currently Foldit works best with the 20 encoded amino acids, so we try to design puzzles with only these residues.

bkoep Staff Lv 1

Sorry, that was an oversight! We will be sure to include the Blueprint in future puzzles!