Placeholder image of a protein
Icon representing a puzzle

1776: Symmetric Tetramer Design: H-bond Networks

Closed since about 6 years ago

Intermediate Overall Design Symmetry

Summary


Created
December 21, 2019
Expires
Max points
100
Description

Design a symmetric tetramer, with 4 identical chains that assemble together. The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.

Top groups


  1. Avatar for Beta Folders 100 pts. 20,592
  2. Avatar for Go Science 2. Go Science 70 pts. 20,382
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 47 pts. 20,368
  4. Avatar for Contenders 4. Contenders 30 pts. 20,324
  5. Avatar for Gargleblasters 5. Gargleblasters 19 pts. 20,085
  6. Avatar for Void Crushers 6. Void Crushers 11 pts. 20,000
  7. Avatar for Marvin's bunch 7. Marvin's bunch 7 pts. 19,687
  8. Avatar for Russian team 8. Russian team 4 pts. 18,995
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 2 pts. 18,564
  10. Avatar for Team Schleswig-Holstein 10. Team Schleswig-Holstein 1 pt. 18,508

  1. Avatar for retiredmichael
    1. retiredmichael Lv 1
    100 pts. 20,592
  2. Avatar for grogar7 2. grogar7 Lv 1 95 pts. 20,368
  3. Avatar for Bruno Kestemont 3. Bruno Kestemont Lv 1 90 pts. 20,357
  4. Avatar for johnmitch 4. johnmitch Lv 1 85 pts. 20,098
  5. Avatar for Timo van der Laan 5. Timo van der Laan Lv 1 81 pts. 20,000
  6. Avatar for Enzyme 6. Enzyme Lv 1 76 pts. 19,994
  7. Avatar for NinjaGreg 7. NinjaGreg Lv 1 72 pts. 19,971
  8. Avatar for Galaxie 8. Galaxie Lv 1 68 pts. 19,959
  9. Avatar for ZeroLeak7 9. ZeroLeak7 Lv 1 64 pts. 19,930
  10. Avatar for Phyx 10. Phyx Lv 1 60 pts. 19,920

Comments


bkoep Staff Lv 1

Core Existence: Monomer (max +2800)
Ensures that at least 19 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network:
Rewards networks that comprise at least two H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

vakobo Lv 1

I have 8 H-Bond networks (two symmetric rings) with 2 H-Bonds each (100% polars satisfied) but only 6 of them are credited with 400 bonus points. Thereby insteed of 3200 i've got only 2400 bonus points. Is there limit of 12 H-Bonds?

bkoep Staff Lv 1

Bonuses are only awarded for maximum 12 H-bonds in networks. Sorry if that wasn't clear in the Objectives description!