Placeholder image of a protein
Icon representing a puzzle

1809: Symmetric Trimer Design: H-Bond Networks

Closed since about 6 years ago

Intermediate Overall Design Symmetry

Summary

Created
March 07, 2020
Expires
Max points
100
Description

Design a symmetric trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective so that no more than 50% of residues may form helices. The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 21,679
  2. Avatar for Go Science 2. Go Science 71 pts. 21,536
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 49 pts. 21,232
  4. Avatar for Beta Folders 4. Beta Folders 33 pts. 21,149
  5. Avatar for Void Crushers 5. Void Crushers 22 pts. 20,517
  6. Avatar for Gargleblasters 6. Gargleblasters 14 pts. 20,083
  7. Avatar for HMT heritage 7. HMT heritage 8 pts. 19,284
  8. Avatar for Hold My Beer 8. Hold My Beer 5 pts. 17,774
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 3 pts. 17,724
  10. Avatar for Marvin's bunch 10. Marvin's bunch 2 pts. 17,462
  1. Avatar for tlaran 41. tlaran Lv 1 30 pts. 17,332
  2. Avatar for WBarme1234 42. WBarme1234 Lv 1 29 pts. 17,215
  3. Avatar for knotartist 43. knotartist Lv 1 28 pts. 17,212
  4. Avatar for haabermaaster 44. haabermaaster Lv 1 27 pts. 16,996
  5. Avatar for Willyanto 45. Willyanto Lv 1 26 pts. 16,934
  6. Avatar for diamonddays 46. diamonddays Lv 1 25 pts. 16,798
  7. Avatar for Pawel Tluscik 47. Pawel Tluscik Lv 1 24 pts. 16,756
  8. Avatar for Dhalion 48. Dhalion Lv 1 23 pts. 16,748
  9. Avatar for abiogenesis 49. abiogenesis Lv 1 23 pts. 16,615
  10. Avatar for ShadowTactics 50. ShadowTactics Lv 1 22 pts. 16,273

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2200)
Ensures that at least 22 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least two H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.