Placeholder image of a protein
Icon representing a puzzle

1812: Symmetric Trimer Design: H-Bond Networks

Closed since almost 6 years ago

Intermediate Overall Design Symmetry

Summary

Created
March 13, 2020
Expires
Max points
100
Description

Design a symmetric protein trimer, with 3 identical chains that assemble together! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 19,896
  2. Avatar for Contenders 2. Contenders 70 pts. 19,797
  3. Avatar for Go Science 3. Go Science 47 pts. 19,758
  4. Avatar for Beta Folders 4. Beta Folders 30 pts. 19,654
  5. Avatar for Gargleblasters 5. Gargleblasters 19 pts. 19,208
  6. Avatar for Void Crushers 6. Void Crushers 11 pts. 19,129
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 7 pts. 18,994
  8. Avatar for Marvin's bunch 8. Marvin's bunch 4 pts. 18,080
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 2 pts. 17,404
  10. Avatar for HMT heritage 10. HMT heritage 1 pt. 16,439
  1. Avatar for mrbar42 71. mrbar42 Lv 1 16 pts. 14,991
  2. Avatar for kathy65 72. kathy65 Lv 1 16 pts. 14,981
  3. Avatar for John McLeod 73. John McLeod Lv 1 15 pts. 14,961
  4. Avatar for NeLikomSheet 74. NeLikomSheet Lv 1 15 pts. 14,885
  5. Avatar for Dj-P 75. Dj-P Lv 1 14 pts. 14,845
  6. Avatar for Dropdeadx890 76. Dropdeadx890 Lv 1 14 pts. 14,798
  7. Avatar for Amphimixus 77. Amphimixus Lv 1 14 pts. 14,734
  8. Avatar for Formula350 78. Formula350 Lv 1 13 pts. 14,624
  9. Avatar for JustinRothganger 79. JustinRothganger Lv 1 13 pts. 14,577
  10. Avatar for infjamc 80. infjamc Lv 1 12 pts. 14,563

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least two H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.