Placeholder image of a protein
Icon representing a puzzle

Protein Design Sandbox

Closed since about 4 years ago

Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for Deleted group 41. Deleted group pts. 8,693
  2. Avatar for Richard Dawkins Foundation 42. Richard Dawkins Foundation 5 pts. 8,665
  3. Avatar for Mercer_F20_BMB465_Crawford 43. Mercer_F20_BMB465_Crawford 4 pts. 8,579
  4. Avatar for Deleted group 44. Deleted group pts. 8,418
  5. Avatar for Columbia Univ CHEN 4800 Summer 2021 45. Columbia Univ CHEN 4800 Summer 2021 3 pts. 8,407
  6. Avatar for Team Canada 46. Team Canada 3 pts. 8,406
  7. Avatar for HMT heritage 47. HMT heritage 3 pts. 8,388
  8. Avatar for GBHS BMAH kids 48. GBHS BMAH kids 3 pts. 8,145
  9. Avatar for bmd 49. bmd 2 pts. 7,780
  10. Avatar for Titans of Biology 50. Titans of Biology 2 pts. 7,684
  1. Avatar for amarfx 1511. amarfx Lv 1 1 pt. 0
  2. Avatar for Vater_Ashley 1512. Vater_Ashley Lv 1 1 pt. 0
  3. Avatar for Curiosity_the_cat 1513. Curiosity_the_cat Lv 1 1 pt. 0
  4. Avatar for skando 1514. skando Lv 1 1 pt. 0
  5. Avatar for gyunghee 1515. gyunghee Lv 1 1 pt. 0
  6. Avatar for EmilyF 1516. EmilyF Lv 1 1 pt. 0
  7. Avatar for Orkman 1517. Orkman Lv 1 1 pt. 0
  8. Avatar for srivani kottam 1518. srivani kottam Lv 1 1 pt. 0
  9. Avatar for allosterisch 1519. allosterisch Lv 1 1 pt. 0
  10. Avatar for MiaRidgway 1520. MiaRidgway Lv 1 1 pt. 0

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)