Placeholder image of a protein
Icon representing a puzzle

1853: Symmetric Trimer Design: Buried Unsats

Closed since over 5 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 18, 2020
Expires
Max points
100
Description

Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, which penalizes buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 23,241
  2. Avatar for Go Science 2. Go Science 73 pts. 23,221
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 52 pts. 23,070
  4. Avatar for Gargleblasters 4. Gargleblasters 36 pts. 22,878
  5. Avatar for Void Crushers 5. Void Crushers 24 pts. 22,512
  6. Avatar for Beta Folders 6. Beta Folders 16 pts. 21,777
  7. Avatar for Marvin's bunch 7. Marvin's bunch 10 pts. 20,642
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 6 pts. 19,229
  9. Avatar for Hold My Beer 9. Hold My Beer 4 pts. 18,467
  10. Avatar for SETI.Germany 10. SETI.Germany 2 pts. 17,952
  1. Avatar for Todd6485577 71. Todd6485577 Lv 1 7 pts. 18,467
  2. Avatar for jawz101 72. jawz101 Lv 1 6 pts. 18,402
  3. Avatar for HuubR 73. HuubR Lv 1 6 pts. 18,183
  4. Avatar for momadoc 74. momadoc Lv 1 6 pts. 18,115
  5. Avatar for AlkiP0Ps 75. AlkiP0Ps Lv 1 5 pts. 17,975
  6. Avatar for sitlux 76. sitlux Lv 1 5 pts. 17,970
  7. Avatar for aendgraend 77. aendgraend Lv 1 5 pts. 17,952
  8. Avatar for Bucsan 78. Bucsan Lv 1 5 pts. 17,873
  9. Avatar for jsfoldingaccount 79. jsfoldingaccount Lv 1 4 pts. 17,852
  10. Avatar for sciencewalker 80. sciencewalker Lv 1 4 pts. 17,745

Comments

bkoep Staff Lv 1

Buried Unsats (max +300)
Penalizes polar atoms that cannot make hydrogen bonds, -30 points per atom (not including symmetric copies).

Core Existence: Monomer (max +3000)
Ensures that at least 30 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least two H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.