Placeholder image of a protein
Icon representing a puzzle

1858: Symmetric Trimer Design: Buried Unsats

Closed since over 5 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 01, 2020
Expires
Max points
100
Description

Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, which penalizes buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 21,251
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 74 pts. 21,198
  3. Avatar for Contenders 3. Contenders 54 pts. 20,666
  4. Avatar for Void Crushers 4. Void Crushers 38 pts. 20,485
  5. Avatar for Gargleblasters 5. Gargleblasters 27 pts. 20,295
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 18 pts. 19,499
  7. Avatar for Beta Folders 7. Beta Folders 12 pts. 19,144
  8. Avatar for Foldit Staff 8. Foldit Staff 8 pts. 18,506
  9. Avatar for BOINC@Poland 9. BOINC@Poland 5 pts. 17,601
  10. Avatar for Russian team 10. Russian team 3 pts. 16,842
  1. Avatar for Philzord 71. Philzord Lv 1 6 pts. 16,906
  2. Avatar for sciencewalker 72. sciencewalker Lv 1 6 pts. 16,898
  3. Avatar for BNet 73. BNet Lv 1 5 pts. 16,875
  4. Avatar for tom2705 74. tom2705 Lv 1 5 pts. 16,869
  5. Avatar for kyoota 75. kyoota Lv 1 5 pts. 16,842
  6. Avatar for aznarog 76. aznarog Lv 1 5 pts. 16,823
  7. Avatar for AlkiP0Ps 77. AlkiP0Ps Lv 1 4 pts. 16,767
  8. Avatar for skovz99 78. skovz99 Lv 1 4 pts. 16,701
  9. Avatar for ManVsYard 79. ManVsYard Lv 1 4 pts. 16,672
  10. Avatar for Pawel Tluscik 80. Pawel Tluscik Lv 1 4 pts. 16,602

Comments

bkoep Staff Lv 1

Buried Unsats (max +300)
Penalizes polar atoms that cannot make hydrogen bonds, -60 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2200)
Ensures that at least 22 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 3 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

grogar7 Lv 1

Puzzle 1858 and Foldit website are giving me credit for 21152 points on this puzzle, when that is a score with BUNS Filter turned OFF. Best credit score is actually 21086!

Bletchley Park Lv 1

Thank you grogar7 for reporting it ! This means that this client should be invalidated for new puzzles to prevent players from abusing this scoring loophole.