Placeholder image of a protein
Icon representing a puzzle

1861: Symmetric Trimer Design: Buried Unsats

Closed since over 5 years ago

Intermediate Overall Design Symmetry

Summary

Created
July 08, 2020
Expires
Max points
100
Description

Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 18,487
  2. Avatar for Go Science 2. Go Science 74 pts. 18,127
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 54 pts. 18,027
  4. Avatar for Gargleblasters 4. Gargleblasters 38 pts. 17,988
  5. Avatar for Void Crushers 5. Void Crushers 27 pts. 17,177
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 18 pts. 16,925
  7. Avatar for Beta Folders 7. Beta Folders 12 pts. 16,703
  8. Avatar for Marvin's bunch 8. Marvin's bunch 8 pts. 16,298
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 5 pts. 16,080
  10. Avatar for Russian team 10. Russian team 3 pts. 14,795
  1. Avatar for dldahlen 81. dldahlen Lv 1 2 pts. 14,503
  2. Avatar for Superphosphate 82. Superphosphate Lv 1 2 pts. 14,375
  3. Avatar for Pawel Tluscik 83. Pawel Tluscik Lv 1 2 pts. 14,360
  4. Avatar for JSmith48 84. JSmith48 Lv 1 2 pts. 14,336
  5. Avatar for bkoep 85. bkoep Lv 1 1 pt. 14,278
  6. Avatar for Tans8b07 86. Tans8b07 Lv 1 1 pt. 14,268
  7. Avatar for abiogenesis 87. abiogenesis Lv 1 1 pt. 14,137
  8. Avatar for tzugypsyl 88. tzugypsyl Lv 1 1 pt. 14,108
  9. Avatar for Dr.Sillem 89. Dr.Sillem Lv 1 1 pt. 14,098
  10. Avatar for CAN1958 90. CAN1958 Lv 1 1 pt. 14,095

Comments

bkoep Staff Lv 1

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +1700 +1600)
Ensures that at least 17 16 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 3 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.