1989: Symmetric Tetramer Design: H-bond Networks

Closed since almost 5 years ago

Summary

• Created: May 05, 2021
• Expires: May 12, 2021 at 23:00 UTC
• Max points: 100

Description

Design a symmetric protein tetramer, with 4 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

• 11. Team China 1 pt. 15,763
• 12. Trinity Biology 1 pt. 0
• 13. Czech National Team 1 pt. 0
• 14. 104-Biology (2020) 1 pt. 0
• 15. Foldit Staff 1 pt. 0

Top soloists

• 101. Seigo 1 pt. 0
• 102. mariya_gladysheva_104 1 pt. 0
• 103. Churbanova Mariya 1 pt. 0
• 104. pyc0208 1 pt. 0
• 105. Lereveur 1 pt. 0

Comments

[Skippysk8s]

the tetramers seem prone to crashing. I don't know if it is size or something else. Basic recipes that either mutate or even just drw or dremix crash frequently. Kind of frustrating

[HuubR]

Tested my two saved solutions with the new devprev release (20210513-dcafd2c0c1-win_x86-devprev). With exactly the same setup, except for this new release, both solutions run smoothly.
Wish we would have had this release a couple days earlier (before the puzzle closed ;-), but still: thank you, devs!