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1989: Symmetric Tetramer Design: H-bond Networks

Closed since almost 5 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 05, 2021
Expires
Max points
100
Description

Design a symmetric protein tetramer, with 4 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

  1. Avatar for Team China 11. Team China 1 pt. 15,763
  2. Avatar for Trinity Biology 12. Trinity Biology 1 pt. 0
  3. Avatar for Czech National Team 13. Czech National Team 1 pt. 0
  4. Avatar for 104-Biology (2020) 14. 104-Biology (2020) 1 pt. 0
  5. Avatar for Foldit Staff 15. Foldit Staff 1 pt. 0
  1. Avatar for WBarme1234 51. WBarme1234 Lv 1 4 pts. 16,407
  2. Avatar for jamiexq 52. jamiexq Lv 1 4 pts. 16,094
  3. Avatar for jobo0502 53. jobo0502 Lv 1 4 pts. 16,034
  4. Avatar for cjddig 54. cjddig Lv 1 3 pts. 15,976
  5. Avatar for ShadowTactics 55. ShadowTactics Lv 1 3 pts. 15,895
  6. Avatar for REDing 56. REDing Lv 1 3 pts. 15,763
  7. Avatar for donuts554 57. donuts554 Lv 1 3 pts. 15,624
  8. Avatar for Larini 58. Larini Lv 1 2 pts. 15,568
  9. Avatar for Altercomp 59. Altercomp Lv 1 2 pts. 14,998
  10. Avatar for mwm64 60. mwm64 Lv 1 2 pts. 14,653

Comments

Skippysk8s Lv 1

the tetramers seem prone to crashing. I don't know if it is size or something else. Basic recipes that either mutate or even just drw or dremix crash frequently. Kind of frustrating

HuubR Lv 1

Tested my two saved solutions with the new devprev release (20210513-dcafd2c0c1-win_x86-devprev). With exactly the same setup, except for this new release, both solutions run smoothly.
Wish we would have had this release a couple days earlier (before the puzzle closed ;-), but still: thank you, devs!