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1989: Symmetric Tetramer Design: H-bond Networks

Closed since almost 5 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 05, 2021
Expires
Max points
100
Description

Design a symmetric protein tetramer, with 4 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

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Comments

Skippysk8s Lv 1

the tetramers seem prone to crashing. I don't know if it is size or something else. Basic recipes that either mutate or even just drw or dremix crash frequently. Kind of frustrating

HuubR Lv 1

Tested my two saved solutions with the new devprev release (20210513-dcafd2c0c1-win_x86-devprev). With exactly the same setup, except for this new release, both solutions run smoothly.
Wish we would have had this release a couple days earlier (before the puzzle closed ;-), but still: thank you, devs!