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1992: Symmetric D2 Tetramer Design: H-bond Networks

Closed since almost 5 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 13, 2021
Expires
Max points
100
Description

Design a D2 symmetric protein tetramer, with 4 identical chains that assemble together! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

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Comments

ichwilldiesennamen Lv 1

For me the likelihood of crashes increases with the number of residues. The 60s are very well playable. 90s are a nightmare.
Try this workaround: https://fold.it/portal/node/2011479
This makes things MUCH more stable for me on every puzzle.
Crashes seem to be related on the amount of data stored for undo.
I sincirely hope this gets looked at by the developers soon and fixed. THAT would REALLY be an improvement to gameplay and attract more players.

BootsMcGraw Lv 1

Since posting, I have tried re-aligning the monomers into another orientation, to see if this was a one-off.

Every time I run a script to make H-bonds, I get these impossible bonds forming. This is a bug. Will file a feedback.

grogar7 Lv 1

Thanks for the reply, ichwilldiesennamen :) I will try this the next time I have problems!