Design of the Month: December 2021

Closed since about 4 years ago

Summary

• Created: November 30, 2021
• Expires: December 31, 2021 at 23:00 UTC
• Max points: 100

Description

This sandbox puzzle features a small molecule design by an anonymous player in Puzzle 2062: VHL Ligand Design: Round 2. The central structure of this molecule has been modified with an aromatic ring system, which backs up a key hydroxyl that makes two critical H-bonds to the target protein. Keep an eye on the cLogP and TPSA Objectives to strike a balance between the hydrophobic and polar atoms in your small molecule designs! For more, check out Foldit Lab Report #27 on YouTube! This sandbox puzzle is non-competitive and will not award any points.



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