Placeholder image of a protein
Icon representing a puzzle

Design of the Month: December 2021

Closed since about 4 years ago

Intermediate

Summary

Created
November 30, 2021
Expires
Max points
100
Description

This sandbox puzzle features a small molecule design by an anonymous player in Puzzle 2062: VHL Ligand Design: Round 2. The central structure of this molecule has been modified with an aromatic ring system, which backs up a key hydroxyl that makes two critical H-bonds to the target protein. Keep an eye on the cLogP and TPSA Objectives to strike a balance between the hydrophobic and polar atoms in your small molecule designs! For more, check out Foldit Lab Report #27 on YouTube! This sandbox puzzle is non-competitive and will not award any points.



Remember, if you want to see your username in updates, make sure to fill out our username sharing form!

Top groups

  1. Avatar for Italiani Al Lavoro 11. Italiani Al Lavoro 2 pts. 19,587
  2. Avatar for Void Crushers 12. Void Crushers 1 pt. 19,560
  3. Avatar for Contenders 13. Contenders 1 pt. 19,557
  4. Avatar for BOINC@Poland 14. BOINC@Poland 1 pt. 19,552
  5. Avatar for Trinity Biology 15. Trinity Biology 1 pt. 19,549
  6. Avatar for Russian team 16. Russian team 1 pt. 19,546
  7. Avatar for Coastal Biochemistry 17. Coastal Biochemistry 1 pt. 19,528
  8. Avatar for Foldit Staff 18. Foldit Staff 1 pt. 16,676
  9. Avatar for Genetics 1 19. Genetics 1 1 pt. 16,676
  1. Avatar for heyubob 31. heyubob Lv 1 20 pts. 19,606
  2. Avatar for Wiz kid 32. Wiz kid Lv 1 19 pts. 19,606
  3. Avatar for MicElephant 33. MicElephant Lv 1 17 pts. 19,595
  4. Avatar for Bruno Kestemont 34. Bruno Kestemont Lv 1 16 pts. 19,595
  5. Avatar for deus911 35. deus911 Lv 1 15 pts. 19,587
  6. Avatar for abiogenesis 36. abiogenesis Lv 1 14 pts. 19,587
  7. Avatar for amazzetti 37. amazzetti Lv 1 13 pts. 19,587
  8. Avatar for vuvuvu 38. vuvuvu Lv 1 12 pts. 19,587
  9. Avatar for jausmh 39. jausmh Lv 1 12 pts. 19,587
  10. Avatar for LELE1964 40. LELE1964 Lv 1 11 pts. 19,586

Comments