Placeholder image of a protein
Icon representing a puzzle

Design of the Month: December 2021

Closed since about 4 years ago

Intermediate

Summary

Created
November 30, 2021
Expires
Max points
100
Description

This sandbox puzzle features a small molecule design by an anonymous player in Puzzle 2062: VHL Ligand Design: Round 2. The central structure of this molecule has been modified with an aromatic ring system, which backs up a key hydroxyl that makes two critical H-bonds to the target protein. Keep an eye on the cLogP and TPSA Objectives to strike a balance between the hydrophobic and polar atoms in your small molecule designs! For more, check out Foldit Lab Report #27 on YouTube! This sandbox puzzle is non-competitive and will not award any points.



Remember, if you want to see your username in updates, make sure to fill out our username sharing form!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 20,091
  2. Avatar for Go Science 2. Go Science 76 pts. 19,998
  3. Avatar for Czech National Team 3. Czech National Team 56 pts. 19,861
  4. Avatar for L'Alliance Francophone 4. L'Alliance Francophone 41 pts. 19,842
  5. Avatar for AlphaFold 5. AlphaFold 29 pts. 19,746
  6. Avatar for Anthropic Dreams 6. Anthropic Dreams 20 pts. 19,669
  7. Avatar for Beta Folders 7. Beta Folders 14 pts. 19,660
  8. Avatar for Marvin's bunch 8. Marvin's bunch 9 pts. 19,649
  9. Avatar for Australia 9. Australia 6 pts. 19,606
  10. Avatar for foldeRNA 10. foldeRNA 4 pts. 19,587
  1. Avatar for Legend Silver 81. Legend Silver Lv 1 1 pt. 19,495
  2. Avatar for artsyambie6 82. artsyambie6 Lv 1 1 pt. 19,494
  3. Avatar for rboul 83. rboul Lv 1 1 pt. 19,493
  4. Avatar for cjw_o3o 84. cjw_o3o Lv 1 1 pt. 19,493
  5. Avatar for pitermarried 85. pitermarried Lv 1 1 pt. 19,492
  6. Avatar for 5tyu6f 86. 5tyu6f Lv 1 1 pt. 19,484
  7. Avatar for pr0tfold 87. pr0tfold Lv 1 1 pt. 19,101
  8. Avatar for Devilbloody 88. Devilbloody Lv 1 1 pt. 18,412
  9. Avatar for jobo0502 89. jobo0502 Lv 1 1 pt. 18,399
  10. Avatar for Grangrenita 90. Grangrenita Lv 1 1 pt. 18,254

Comments