Icon representing a puzzle

2198: Protein Design with Neural Net Mutate

Closed since over 3 years ago

Intermediate Overall Design

Summary

Created
September 10, 2022
Expires
Max points
100
Description

This puzzle debuts the new Neural Net Mutate action! This tool uses an AI algorithm to predict a protein sequence that will fold into a give structure. Note that Neural Net Mutate does not fold sidechains like classic Mutate, so you will probably want to run Shake after mutating. Proteins designed with this AI algorithm tend to have much higher AlphaFold confidence. Read more on the Foldit blog. Or just try it out here to see what kinds of protein designs you can come up with, and how much you can increase the AlphaFold confidence!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 13,123
  2. Avatar for Contenders 2. Contenders 65 pts. 11,620
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 41 pts. 11,577
  4. Avatar for Gargleblasters 4. Gargleblasters 24 pts. 11,189
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 14 pts. 11,001
  6. Avatar for Marvin's bunch 6. Marvin's bunch 7 pts. 10,916
  7. Avatar for Australia 7. Australia 4 pts. 10,838
  8. Avatar for FamilyBarmettler 8. FamilyBarmettler 2 pts. 10,169
  9. Avatar for Foldit Staff 9. Foldit Staff 1 pt. 9,758
  10. Avatar for Ogre's lab 10. Ogre's lab 1 pt. 9,416
  1. Avatar for Crossed Sticks 21. Crossed Sticks Lv 1 26 pts. 11,193
  2. Avatar for cjddig 22. cjddig Lv 1 24 pts. 11,189
  3. Avatar for BootsMcGraw 23. BootsMcGraw Lv 1 22 pts. 11,176
  4. Avatar for BackBuffer 24. BackBuffer Lv 1 20 pts. 11,144
  5. Avatar for Bletchley Park 25. Bletchley Park Lv 1 19 pts. 11,132
  6. Avatar for MicElephant 26. MicElephant Lv 1 17 pts. 11,093
  7. Avatar for stomjoh 27. stomjoh Lv 1 16 pts. 11,062
  8. Avatar for blazegeek 28. blazegeek Lv 1 14 pts. 11,051
  9. Avatar for Alistair69 29. Alistair69 Lv 1 13 pts. 11,001
  10. Avatar for alcor29 30. alcor29 Lv 1 12 pts. 10,972

Comments

MicElephant Lv 1

I don't get the 5 start positions. Only the same long chain, each time I select reset puzzle. Has really the real puzzle been posted?

bkoep Staff Lv 1

@MicElephant
I don't get the 5 start positions. Only the same long chain, each time I select reset puzzle. Has really the real puzzle been posted?

Hmm, there seems to be a bug that prevents multiple starting structures from loading. We're looking into, but unlikely to fix the issue before this puzzle closes.