Icon representing a puzzle

Design of the Month: February 2023

Closed since about 3 years ago

Overall Design

Summary

Created
January 24, 2023
Expires
Max points
0
Description

This sandbox puzzle features a FMN ligand binder design by blazegeek from Puzzle 2248. This design does a great job of burying hydrophobic atoms, with the hydrophobic end of of the FMN ligand target buried in a tightly packed hydrophobic pocket. Since the polar end of FMN is exposed to solvent, this binder does not make many hydrogen bonds to the ligand. This is okay for binding strength, but could hurt the binding specificity, with nothing to stop binding to other hydrophobic ligands. For more, check out the latest Foldit Lab Report on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Top groups

  1. Avatar for Rechenkraft.net 11. Rechenkraft.net 1 pt. 14,582
  2. Avatar for AlphaFold 12. AlphaFold 1 pt. 14,440
  3. Avatar for OmHS 13. OmHS 1 pt. 14,418
  4. Avatar for Street Smarts 14. Street Smarts 1 pt. 14,369
  5. Avatar for Goons with proteins 15. Goons with proteins 1 pt. 14,367
  6. Avatar for Foldit Staff 16. Foldit Staff 1 pt. 14,367
  7. Avatar for Team South Africa 17. Team South Africa 1 pt. 14,367
  8. Avatar for Villanova ChE 18. Villanova ChE 1 pt. 14,367
  1. Avatar for kermyt 41. kermyt Lv 1 1 pt. 14,621
  2. Avatar for evifnoskcaj 42. evifnoskcaj Lv 1 1 pt. 14,619
  3. Avatar for Deleted player 43. Deleted player 1 pt. 14,618
  4. Avatar for heyubob 44. heyubob Lv 1 1 pt. 14,613
  5. Avatar for carxo 45. carxo Lv 1 1 pt. 14,605
  6. Avatar for pruneau_44 46. pruneau_44 Lv 1 1 pt. 14,601
  7. Avatar for william.zenor 47. william.zenor Lv 1 1 pt. 14,592
  8. Avatar for kotenok2000 48. kotenok2000 Lv 1 1 pt. 14,582
  9. Avatar for phi16 49. phi16 Lv 1 1 pt. 14,580
  10. Avatar for spvincent 50. spvincent Lv 1 1 pt. 14,569

Comments