2450: Revisiting Puzzle 786

Closed since almost 2 years ago

Summary

• Created: May 01, 2024
• Expires: May 08, 2024 at 22:00 UTC
• Max points: 100

Description

This is a repost of a De-novo Freestyle puzzle we ran in October of 2013. Your solutions for this puzzle will help us evaluate some features of the recent Foldit updates. Players will NOT be able to load in solutions from Puzzle 786.

Top groups

• 11. BOINC@Poland 1 pt. 9,336
• 12. Gargleblasters 1 pt. 8,691
• 13. 2903_2024 1 pt. 8,122
• 14. Foldit Staff 1 pt. 1,269

Top soloists

• 21. BackBuffer 26 pts. 10,284
• 22. AlkiP0Ps 24 pts. 10,263
• 23. fpc 22 pts. 10,218
• 24. manu8170 21 pts. 10,167
• 25. Dr.Sillem 19 pts. 10,115
• 26. Steven Pletsch 18 pts. 10,106
• 27. jausmh 16 pts. 10,101
• 28. drjr 15 pts. 9,939
• 29. Gerom 14 pts. 9,901
• 30. BarrySampson 13 pts. 9,864

Comments

[LociOiling]

This is only the second revisit to puzzle 786. Puzzle 845 was the first revisit: https://fold.it/puzzles/996898

[LociOiling]

The protein in this puzzle is 2MCT, protein ZP_02042476.1 from Ruminococcus gnavus. The PDB entry is from 2013, but it still shows "to be published".

[LociOiling]

AlphaFold had a go at this protein, great except for the first 22 residues sticking out into space, then the rest looks somewhat OK: https://alphafold.ebi.ac.uk/entry/A7B6R4

So maybe AlphaFold is not infallible?

[Serca]

The first 20 amino acids, which are not present in this puzzle but are present in the Alphafold solution, seem to constitute the signal peptide. That is, they are a part of the protein destined to be removed by intracellular organelles that help to fold it.
https://www.uniprot.org/help/signal

[LociOiling]

Thanks @Serca, I'll have to look at the AlphaFold solution in more detail. I'd assumed that AlphaFold was using the sequence from 2MCT.

Meanwhile, I put together a guide for this puzzle, making it more like the other revisits: https://foldit.fandom.com/wiki/Revisiting_puzzle/786:_De-novo_Freestyle_30