Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Summary

• Created: May 07, 2024
• Expires: August 06, 2024 at 20:00 UTC
• Max points: 100

Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

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Top soloists

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• 28. c_moi_le_robot 80 pts. 12,994
• 29. dong 79 pts. 12,989
• 30. dhj 78 pts. 12,989