Icon representing a puzzle

Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Beginner

Summary

Created
August 14, 2024
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Team China
    1. Team China
    100 pts. 12,039
  2. Avatar for L'Alliance Francophone 2. L'Alliance Francophone 1 pt. 11,753
  1. Avatar for Arlind1 11. Arlind1 Lv 1 22 pts. 12,860
  2. Avatar for acecil 12. acecil Lv 1 19 pts. 12,536
  3. Avatar for Kmemz 13. Kmemz Lv 1 15 pts. 12,469
  4. Avatar for Orbitaz 14. Orbitaz Lv 1 13 pts. 12,172
  5. Avatar for chlfkhf 15. chlfkhf Lv 1 11 pts. 12,039
  6. Avatar for muskaanbal 16. muskaanbal Lv 1 9 pts. 11,999
  7. Avatar for saksham_-_ 17. saksham_-_ Lv 1 7 pts. 11,950
  8. Avatar for fanny 18. fanny Lv 1 6 pts. 11,919
  9. Avatar for fabi.og 19. fabi.og Lv 1 5 pts. 11,907
  10. Avatar for prio92 20. prio92 Lv 1 4 pts. 11,867

Comments