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Beginner Puzzle: Coronavirus

Closed since over 1 year ago

Beginner

Summary

Created
August 14, 2024
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus! This is a Beginner puzzle for new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for Team China
    1. Team China
    100 pts. 12,039
  2. Avatar for L'Alliance Francophone 2. L'Alliance Francophone 1 pt. 11,753
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  3. Avatar for bczero1 23. bczero1 Lv 1 2 pts. 11,753
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  5. Avatar for pufferfsh 25. pufferfsh Lv 1 1 pt. 11,753
  6. Avatar for mminseo 26. mminseo Lv 1 1 pt. 11,753
  7. Avatar for OliviaNoble 27. OliviaNoble Lv 1 1 pt. 11,753
  8. Avatar for 000opl900 28. 000opl900 Lv 1 1 pt. 11,753
  9. Avatar for Intrepid99 29. Intrepid99 Lv 1 1 pt. 11,753
  10. Avatar for kinder_007 30. kinder_007 Lv 1 1 pt. 11,753

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