2503: KCNQ1 Round 10
Closed since over 1 year ago
Intermediate Overall Small Molecule DesignSummary
- Created
- August 27, 2024
- Expires
- Max points
- 100
KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. In this puzzle, your challenge is to design a new activator for KCNQ1 that can restore function in variants linked to LQTS. For this puzzle we're going to switch up the task just a little. Now we want to target the Voltage Sensing Domain (VSD) of KCNQ1. It has been found that mutations to the VSD affect how effectively a protein is transported from its site of synthesis to the plasma membrane also known as trafficking. See blog post for more details, but note that we are looking at a different target site for KCNQ1 for this puzzle.
Join us in this exciting quest to develop new treatments for LQTS and make a real difference in heart health! Your innovative designs could be the key to creating effective therapies for this serious condition.
*Note: While it may be possible to accept compounds not in the Compound Library for further testing, compounds from the CL have the highest likelihood to be selected.
