LociOiling Lv 1
This puzzle starts with an extended chain, consisting entirely of the amino acid isoleucine. See the amino acids page and the amino acid gallery for more on the 20 available amino acids.
The goal is to give it a primary structure, by mutating the starting amino acids. There are three mutate tools available. Neural Net Mutate was the last method added, just before AI eliminated Foldit in protein design. It picks amino acids based on something that a neural net learned somewhere, although it's not clear what exactly that something is.
There's also a manual mutate that lets you mutate selected segments to the amino acid of your choice. Or the automatic mutate tool will mutate all or selected segments to the amino acids of its choice.
It will also need some secondary structure, meaning sheets and helices. (The extended chain is considered to be all loop, but that's just anything that's not a sheet or a helix.)
Here's a quick-and-dirty way to get on the scoreboard using hotkeys:
- control + a to select all
- l, then k to mark everything as helix
- 5 to make an ideal helix
- y to mutate everything (let it run for a while, then stop it)
- s to shake (for a cycle or two)
- w to wiggle (for a while)
Make sure to keep everything selected after the first step.
These steps will probably get you a very straight helix made entirely of lysine. But it should score reasonably well.