Icon representing a puzzle

Beginner Puzzle: Docking Design

Closed since 4 months ago

Beginner

Summary

Created
October 02, 2025
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for VeFold
    1. VeFold
    100 pts. 9,462
  2. Avatar for Go Science 2. Go Science 52 pts. 9,435
  3. Avatar for BIOL2020AB Fall2025 3. BIOL2020AB Fall2025 24 pts. 9,352
  4. Avatar for BIOB101 - Discover Biology 4. BIOB101 - Discover Biology 10 pts. 9,335
  5. Avatar for Antharis Therapeutics 5. Antharis Therapeutics 4 pts. 9,231
  6. Avatar for CS 234 6. CS 234 1 pt. 9,058
  7. Avatar for ddd 7. ddd 1 pt. 9,057
  8. Avatar for UPJ Biochem 25 8. UPJ Biochem 25 1 pt. 6,345
  9. Avatar for MU_BIOCHEM_F2025 9. MU_BIOCHEM_F2025 1 pt. 6,300
  1. Avatar for westchuck
    1. westchuck Lv 1
    100 pts. 9,591
  2. Avatar for zxspectrum 2. zxspectrum Lv 1 96 pts. 9,546
  3. Avatar for mrosee 3. mrosee Lv 1 91 pts. 9,501
  4. Avatar for mammillaria 4. mammillaria Lv 1 87 pts. 9,462
  5. Avatar for <someone> 5. <someone> Lv 1 82 pts. 9,435
  6. Avatar for niurunfolds 6. niurunfolds Lv 1 78 pts. 9,435
  7. Avatar for lisiying 7. lisiying Lv 1 74 pts. 9,374
  8. Avatar for athena99 8. athena99 Lv 1 70 pts. 9,357
  9. Avatar for ZaMir6715 9. ZaMir6715 Lv 1 67 pts. 9,352
  10. Avatar for cronkcalli 10. cronkcalli Lv 1 63 pts. 9,335

Comments