Icon representing a puzzle

Beginner Puzzle: Docking Design

Closed since 4 months ago

Beginner

Summary

Created
October 02, 2025
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For new players that have joined Foldit in the last 6 months.

Top groups

  1. Avatar for VeFold
    1. VeFold
    100 pts. 9,462
  2. Avatar for Go Science 2. Go Science 52 pts. 9,435
  3. Avatar for BIOL2020AB Fall2025 3. BIOL2020AB Fall2025 24 pts. 9,352
  4. Avatar for BIOB101 - Discover Biology 4. BIOB101 - Discover Biology 10 pts. 9,335
  5. Avatar for Antharis Therapeutics 5. Antharis Therapeutics 4 pts. 9,231
  6. Avatar for CS 234 6. CS 234 1 pt. 9,058
  7. Avatar for ddd 7. ddd 1 pt. 9,057
  8. Avatar for UPJ Biochem 25 8. UPJ Biochem 25 1 pt. 6,345
  9. Avatar for MU_BIOCHEM_F2025 9. MU_BIOCHEM_F2025 1 pt. 6,300
  1. Avatar for mattmotor 61. mattmotor Lv 1 2 pts. 8,162
  2. Avatar for fgfadraga 62. fgfadraga Lv 1 1 pt. 7,768
  3. Avatar for Mo Yayuan 63. Mo Yayuan Lv 1 1 pt. 7,615
  4. Avatar for belia ttimpo 64. belia ttimpo Lv 1 1 pt. 7,579
  5. Avatar for jingzhe 65. jingzhe Lv 1 1 pt. 7,558
  6. Avatar for Gooblearner1st 66. Gooblearner1st Lv 1 1 pt. 6,445
  7. Avatar for irohahaa687 67. irohahaa687 Lv 1 1 pt. 6,397
  8. Avatar for fujii 68. fujii Lv 1 1 pt. 6,388
  9. Avatar for nbfi77 69. nbfi77 Lv 1 1 pt. 6,382
  10. Avatar for ZZ1111 70. ZZ1111 Lv 1 1 pt. 6,351

Comments