Placeholder image of a protein
Icon representing a puzzle

366: Back Me Up 1

Closed since over 15 years ago

Intermediate

Summary

Created
September 27, 2010
Expires
Max points
100
Description

We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

Top groups

  1. Avatar for Go Science 11. Go Science 7 pts. 14,108
  2. Avatar for BOINC@Denmark 12. BOINC@Denmark 5 pts. 14,094
  3. Avatar for OMNABEK 13. OMNABEK 4 pts. 14,087
  4. Avatar for Deleted group 14. Deleted group pts. 14,082
  5. Avatar for Slovak National Team 15. Slovak National Team 2 pts. 14,080
  6. Avatar for Penny-Arcade 16. Penny-Arcade 1 pt. 14,070
  7. Avatar for L'Alliance Francophone 17. L'Alliance Francophone 1 pt. 14,064
  8. Avatar for Mmm Helix Fries. 18. Mmm Helix Fries. 1 pt. 14,059
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 14,054
  10. Avatar for xkcd 20. xkcd 1 pt. 14,037
  1. Avatar for dimension9 61. dimension9 Lv 1 32 pts. 14,088
  2. Avatar for 6zebo6 62. 6zebo6 Lv 1 31 pts. 14,087
  3. Avatar for yoyo washington 63. yoyo washington Lv 1 31 pts. 14,086
  4. Avatar for Wilderbeast52 64. Wilderbeast52 Lv 1 30 pts. 14,086
  5. Avatar for erlorad 65. erlorad Lv 1 29 pts. 14,086
  6. Avatar for FWishbringer 66. FWishbringer Lv 1 29 pts. 14,085
  7. Avatar for deus911 67. deus911 Lv 1 28 pts. 14,085
  8. Avatar for fishercat 68. fishercat Lv 1 28 pts. 14,085
  9. Avatar for RyeSnake 69. RyeSnake Lv 1 27 pts. 14,085
  10. Avatar for Ch Garnier 70. Ch Garnier Lv 1 26 pts. 14,084

Comments

beta_helix Staff Lv 1

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.