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423: H2N2 Flu Design Puzzle 1

Closed since almost 15 years ago

Intermediate Overall Design

Summary

Created
May 26, 2011
Expires
Max points
100
Description

This puzzle had an error in it and has been reposted as Puzzle 425, sorry for the trouble with this.

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    1. foldeRNA
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Comments

beta_helix Staff Lv 1

In order to play this exciting puzzle (worth 150 global points) make sure to download the latest update (it should download automatically when launching Foldit).

saksoft2 Lv 1

If I understand our challenge correctly, we are intended to form a binding pocket between some known substance and H2N2. It makes very little sense to me to have both compounds mutatable. One is the virus fragment, the other is our detector molecule (or inhibitor or whatever… ) That should have been the only part of this puzzle we could mutate, right? Which half is which?

I don't see how mutating the target protein is useful to solve the science portion of this challenge. I mean we can't actually mutate the virus to make it more sticky to the other molecule in the wild, can we?

thx