439: H2N2 Flu Design Puzzle 1b

Closed since over 14 years ago

Summary

• Created: July 14, 2011
• Expires: July 21, 2011 at 23:00 UTC
• Max points: 100

Description

This is the first of the many new exciting Flu puzzles David Baker mentioned in his blogpost. Our lab designed against the H1N1 subtype of the virus, but a related subtype with pandemic potential, H2N2, has different sidechains in this region that perturb binding. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. This puzzle is worth 150 global points! If you are new to Foldit, make sure you have completed the Intro Puzzle 4-5 and Design Puzzles 6-1 through 6-4. We've tweaked some parameters since the last time you've seen this protein, so things should be a little different!

Top groups

• 11. Purdue BoilerFolders 8 pts. 7,373
• 12. Slovak National Team 6 pts. 7,365
• 13. Deleted group pts. 7,361
• 14. Freedom Folders 3 pts. 7,351
• 15. University of Washington 2 pts. 7,346
• 16. Natural Abilities 2 pts. 7,343
• 17. Crunching Family 1 pt. 7,337
• 18. Team China 1 pt. 7,331
• 19. Eὕρηκα! Heureka! 1 pt. 7,325
• 20. Argentina 1 pt. 7,320

Top soloists

• 51. Deleted player pts. 7,381
• 52. Origami314 33 pts. 7,381
• 53. scottyler89 32 pts. 7,381
• 54. JasperD 32 pts. 7,381
• 55. Tlaloc 31 pts. 7,380
• 56. gramps 30 pts. 7,380
• 57. deus911 29 pts. 7,378
• 58. lynnai 29 pts. 7,377
• 59. Parclytaxel 28 pts. 7,376
• 60. anthunk 27 pts. 7,376