439: H2N2 Flu Design Puzzle 1b

Closed since over 14 years ago

Summary

• Created: July 14, 2011
• Expires: July 21, 2011 at 23:00 UTC
• Max points: 100

Description

This is the first of the many new exciting Flu puzzles David Baker mentioned in his blogpost. Our lab designed against the H1N1 subtype of the virus, but a related subtype with pandemic potential, H2N2, has different sidechains in this region that perturb binding. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. This puzzle is worth 150 global points! If you are new to Foldit, make sure you have completed the Intro Puzzle 4-5 and Design Puzzles 6-1 through 6-4. We've tweaked some parameters since the last time you've seen this protein, so things should be a little different!

Top groups

• 11. Purdue BoilerFolders 8 pts. 7,373
• 12. Slovak National Team 6 pts. 7,365
• 13. Deleted group pts. 7,361
• 14. Freedom Folders 3 pts. 7,351
• 15. University of Washington 2 pts. 7,346
• 16. Natural Abilities 2 pts. 7,343
• 17. Crunching Family 1 pt. 7,337
• 18. Team China 1 pt. 7,331
• 19. Eὕρηκα! Heureka! 1 pt. 7,325
• 20. Argentina 1 pt. 7,320

Top soloists

• 61. Steve001 26 pts. 7,376
• 62. shettler 26 pts. 7,374
• 63. SKSbell 25 pts. 7,374
• 64. davidla 25 pts. 7,373
• 65. justjustin 24 pts. 7,373
• 66. IHOP26 23 pts. 7,372
• 67. gmn 23 pts. 7,372
• 68. barbaranne 22 pts. 7,370
• 69. PRL 22 pts. 7,369
• 70. aendgraend 21 pts. 7,369