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499: CASP ROLL Puzzle 3 with Disulfides

Closed since about 14 years ago

Beginner Overall Prediction

Summary

Created
December 23, 2011
Expires
Max points
100
Description

This is a repost of the third CASP ROLL target, R0003. Since this target has many Cysteines, we have enabled disulfide bonding for this puzzle. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them. You can load in your previous solutions from Puzzle 495.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 8,558
  2. Avatar for Contenders 2. Contenders 86 pts. 8,555
  3. Avatar for foldeRNA 3. foldeRNA 74 pts. 8,542
  4. Avatar for Go Science 4. Go Science 63 pts. 8,533
  5. Avatar for Androids 5. Androids 53 pts. 8,527
  6. Avatar for Void Crushers 6. Void Crushers 44 pts. 8,527
  7. Avatar for HMT heritage 7. HMT heritage 37 pts. 8,510
  8. Avatar for Russian team 8. Russian team 31 pts. 8,507
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 25 pts. 8,482
  10. Avatar for Atheists, Skeptics, & Humanists 10. Atheists, Skeptics, & Humanists 21 pts. 8,479
  1. Avatar for frood66 11. frood66 Lv 1 85 pts. 8,527
  2. Avatar for Madde 12. Madde Lv 1 84 pts. 8,527
  3. Avatar for RabidNimravid 13. RabidNimravid Lv 1 82 pts. 8,526
  4. Avatar for gdnskye 14. gdnskye Lv 1 81 pts. 8,524
  5. Avatar for Rav3n_pl 15. Rav3n_pl Lv 1 79 pts. 8,522
  6. Avatar for BootsMcGraw 16. BootsMcGraw Lv 1 78 pts. 8,522
  7. Avatar for martinzblavy 17. martinzblavy Lv 1 77 pts. 8,520
  8. Avatar for pauldunn 18. pauldunn Lv 1 75 pts. 8,516
  9. Avatar for Bletchley Park 19. Bletchley Park Lv 1 74 pts. 8,515
  10. Avatar for grabhorn 20. grabhorn Lv 1 73 pts. 8,511

Comments

BootsMcGraw Lv 1

If disulfide bridges are considered important in this puzzle, then why are they scored with such small value?

I was able to make a structure with three solid C-C bonds, which I have worked to score only 8479. The three disulfides score six, six, and seven points, respectively. No player I have talked to has managed to get a disulfide scoring more than eight points.

My best score for this puzzle is 8514, some thirty-five points higher. This structure has no disulfides.

Is the scoring on this puzzle hosed? Or have some of the players been able to make decent secondary structures, and score even higher without the bonds?

If the secondary structure predictions show no helices or sheets, then what else is possibly holding this thing together, except for disulfide bridges?

beta_helix Staff Lv 1

As you can see in Puzzle 503 (http://fold.it/portal/node/991538), the server predictions for this target have very few disulfide bonds as well (as did the top scoring solutions for this puzzle).

I definitely am looking forward to seeing what the native looks like for this one, watch there be only 1 Disulfide Bridge!