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499: CASP ROLL Puzzle 3 with Disulfides

Closed since about 14 years ago

Beginner Overall Prediction

Summary

Created
December 23, 2011
Expires
Max points
100
Description

This is a repost of the third CASP ROLL target, R0003. Since this target has many Cysteines, we have enabled disulfide bonding for this puzzle. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them. You can load in your previous solutions from Puzzle 495.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 8,558
  2. Avatar for Contenders 2. Contenders 86 pts. 8,555
  3. Avatar for foldeRNA 3. foldeRNA 74 pts. 8,542
  4. Avatar for Go Science 4. Go Science 63 pts. 8,533
  5. Avatar for Androids 5. Androids 53 pts. 8,527
  6. Avatar for Void Crushers 6. Void Crushers 44 pts. 8,527
  7. Avatar for HMT heritage 7. HMT heritage 37 pts. 8,510
  8. Avatar for Russian team 8. Russian team 31 pts. 8,507
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 25 pts. 8,482
  10. Avatar for Atheists, Skeptics, & Humanists 10. Atheists, Skeptics, & Humanists 21 pts. 8,479
  1. Avatar for Hanto_FZ140E_4G 21. Hanto_FZ140E_4G Lv 1 71 pts. 8,510
  2. Avatar for RitaGrommii 22. RitaGrommii Lv 1 70 pts. 8,507
  3. Avatar for steveB 23. steveB Lv 1 69 pts. 8,504
  4. Avatar for histon 24. histon Lv 1 68 pts. 8,503
  5. Avatar for dembones 25. dembones Lv 1 67 pts. 8,502
  6. Avatar for gmn 26. gmn Lv 1 65 pts. 8,501
  7. Avatar for Tony Origami 27. Tony Origami Lv 1 64 pts. 8,501
  8. Avatar for spmm 28. spmm Lv 1 63 pts. 8,490
  9. Avatar for karstenw 29. karstenw Lv 1 62 pts. 8,483
  10. Avatar for pvc78 30. pvc78 Lv 1 61 pts. 8,483

Comments

BootsMcGraw Lv 1

If disulfide bridges are considered important in this puzzle, then why are they scored with such small value?

I was able to make a structure with three solid C-C bonds, which I have worked to score only 8479. The three disulfides score six, six, and seven points, respectively. No player I have talked to has managed to get a disulfide scoring more than eight points.

My best score for this puzzle is 8514, some thirty-five points higher. This structure has no disulfides.

Is the scoring on this puzzle hosed? Or have some of the players been able to make decent secondary structures, and score even higher without the bonds?

If the secondary structure predictions show no helices or sheets, then what else is possibly holding this thing together, except for disulfide bridges?

beta_helix Staff Lv 1

As you can see in Puzzle 503 (http://fold.it/portal/node/991538), the server predictions for this target have very few disulfide bonds as well (as did the top scoring solutions for this puzzle).

I definitely am looking forward to seeing what the native looks like for this one, watch there be only 1 Disulfide Bridge!