Placeholder image of a protein
Icon representing a puzzle

522b: Flu Design Puzzle 5

Closed since about 14 years ago

Advanced Overall Design

Summary

Created
February 25, 2012
Expires
Max points
100
Description

This puzzle is about trying to build a scaffold around a known binding helix to the H1 flu. We already have a few designs that we like from the computers that you can use as inspiration (see puzzle comments). While our designs are based on proteins that are known to exist, we are excited to see what you can build from scratch.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 11,375
  2. Avatar for Void Crushers 2. Void Crushers 88 pts. 11,370
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 77 pts. 11,362
  4. Avatar for foldeRNA 4. foldeRNA 67 pts. 11,327
  5. Avatar for Androids 5. Androids 58 pts. 11,327
  6. Avatar for Go Science 6. Go Science 50 pts. 11,277
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 43 pts. 11,265
  8. Avatar for Deleted group 8. Deleted group pts. 11,265
  9. Avatar for Deleted group 9. Deleted group pts. 11,192
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 26 pts. 11,150
  1. Avatar for Mark- 21. Mark- Lv 1 79 pts. 11,257
  2. Avatar for Ch Garnier 22. Ch Garnier Lv 1 78 pts. 11,256
  3. Avatar for anthunk 23. anthunk Lv 1 77 pts. 11,254
  4. Avatar for pauldunn 24. pauldunn Lv 1 76 pts. 11,249
  5. Avatar for mimi 25. mimi Lv 1 75 pts. 11,246
  6. Avatar for glaciall 26. glaciall Lv 1 74 pts. 11,246
  7. Avatar for mbinfield 27. mbinfield Lv 1 73 pts. 11,245
  8. Avatar for spmm 28. spmm Lv 1 73 pts. 11,234
  9. Avatar for gramps 29. gramps Lv 1 72 pts. 11,225
  10. Avatar for karstenw 30. karstenw Lv 1 71 pts. 11,223

Comments

beta_helix Staff Lv 1



____________
More info about this Flu Puzzle:

In this Foldit puzzle the helix is frozen, but you can mutate some of the residues on it.
We want you to build & design both sections on either side of the helix.
To keep the helix from moving, we have cut both those sections on either side of the helix so you can work on them with affecting the helix.
You will notice that both ends have very strong constraints to the either side of the helix.

As discussed in the Scientist Chat (http://fold.it/portal/node/991963) we have also added minimal constraints to keep these two sections in the same general area as the above screenshots.
We have also trimmed as much of the Flu as possible and frozen all its sidechains to speed up Shake and Wiggle.

TimothyPatrick Lv 1

I don't see any other comments on here about their FoldIt application constantly crashing on this puzzle so I am assuming I am one of the few that it is happening to. FoldIt will only run for about five minutes before it crashes (even when I only use the basic functions under Modes and Action). I am still a Rookie at this but I have not had this problem before and I have been playing a lot since January of this year. I am on an Win XP laptop so this might be an issue.

beta_helix Staff Lv 1

Can you send us the last few lines of your log.txt right after a crash? (Before you relaunch Foldit).

You'll find your log.txt file here:

on Windows:
if you installed after 8/23/2011, they will be in your installation directory (the default is C:\Program Files\Foldit\ or C:\Program Files (x86)\Foldit)
if you installed prior to 8/23/2011:
on Windows XP at C:\Documents and Settings\All Users\Application Data\Foldit\
on Windows 7 and Vista at C:\ProgramData\Foldit\