Placeholder image of a protein
Icon representing a puzzle

549: Beginner Immunotherapy Design Puzzle 2

Closed since almost 14 years ago

Beginner Overall Design

Summary

Created
April 26, 2012
Expires
Max points
100
Description

We are giving you a 8 residue long helix that you are able to mutate & dock onto the native binding region which is indicated by the side chains that are allowed to shake. Try to look for favorable hydrophobic interactions and strong hydrogen bonds, while maintaining the helix! If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More info in the Puzzle Comments.

Top groups

  1. Avatar for Deleted group 21. Deleted group pts. 9,140
  2. Avatar for Czech National Team 22. Czech National Team 1 pt. 9,129
  3. Avatar for Valencia 23. Valencia 1 pt. 9,126
  4. Avatar for Geekdo 24. Geekdo 1 pt. 9,122
  5. Avatar for BOINC@Poland 25. BOINC@Poland 1 pt. 9,116
  6. Avatar for Trinity 26. Trinity 1 pt. 9,114
  7. Avatar for Mmm Helix Fries. 27. Mmm Helix Fries. 1 pt. 9,109
  8. Avatar for Team Germany 28. Team Germany 1 pt. 9,106
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 0
  1. Avatar for relemzidin 301. relemzidin Lv 1 1 pt. 9,080
  2. Avatar for Stiven42 302. Stiven42 Lv 1 1 pt. 9,080
  3. Avatar for Ironcode 303. Ironcode Lv 1 1 pt. 9,080
  4. Avatar for TeaMonkey 304. TeaMonkey Lv 1 1 pt. 9,079
  5. Avatar for Egil 305. Egil Lv 1 1 pt. 9,079
  6. Avatar for TheCulture 306. TheCulture Lv 1 1 pt. 9,078
  7. Avatar for dikech 307. dikech Lv 1 1 pt. 9,075
  8. Avatar for ourtown 308. ourtown Lv 1 1 pt. 9,074
  9. Avatar for lyx 309. lyx Lv 1 1 pt. 9,073
  10. Avatar for panthael 310. panthael Lv 1 1 pt. 9,071

Comments

beta_helix Staff Lv 1

Since the first Immunotherapy Design Puzzle (539) gave really interesting results, we start off with a new one in this series. The goal is again to find a solution which binds the CTLA-4 protein (more background here: http://fold.it/portal/node/992285), however you are now targeting the native binding site of the CTLA-4 protein. Nature already came up with a beta-sheet which is capable of binding this region, we are now searching for a helix to interact with the site.

and please check out the blogpost about this: http://fold.it/portal/node/992498

mbinfield Lv 1

In a future iteration, can we have slightly weaker constraints on the binding site? I'd like to work in the area around 91, which is just far enough away that the constraint makes it difficult, but I think you could get good interactions there.

EvdH Lv 1

It is indeed an interesting area with the hydrophobic over there, but since Ile91 is relatively far away from the natural binding site, it is constrained in this puzzle.

mbinfield Lv 1

Ah, thanks. I was thinking maybe it would still be close enough to interfere with the natural binding site, maybe depending on the backbone behind the helix.